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Sulindac Causing a Hypersensitivity Reaction with Peripheral and Mediastinal Lymphadenopathy

Ann Intern Med. 1982;97(4):564-565. doi:10.7326/0003-4819-97-4-564
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Sulindac, one of the newer nonsteroidal anti-inflammatory agents, has gained popularity because it can be taken twice a day and has few adverse effects. Reactions to sulindac include hepatotoxicity (1), bone marrow aplasia (2), acute febrile hypersensitivity reactions (3, 4), and Stevens-Johnson syndrome (5). More common side effects include nausea, vomiting, rashes, and headaches. This report describes a febrile hypersensitivity reaction with concomitant splenomegaly and mediastinal as well as general peripheral lymphadenopathy.

A 61-year-old white man presented with a 10-day history of headache, fever, rash, malaise, and lymphadenopathy. This condition had occurred 1 year earlier, lasting 6 weeks, with complete


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