Sulindac, one of the newer nonsteroidal anti-inflammatory agents, has gained popularity because it can be taken twice a day and has few adverse effects. Reactions to sulindac include hepatotoxicity (1), bone marrow aplasia (2), acute febrile hypersensitivity reactions (3, 4), and Stevens-Johnson syndrome (5). More common side effects include nausea, vomiting, rashes, and headaches. This report describes a febrile hypersensitivity reaction with concomitant splenomegaly and mediastinal as well as general peripheral lymphadenopathy.
A 61-year-old white man presented with a 10-day history of headache, fever, rash, malaise, and lymphadenopathy. This condition had occurred 1 year earlier, lasting 6 weeks, with complete