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Toxic Shock Syndrome: A Reprise

EDWARD H. KASS, M.D., PH.D.
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Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital; Boston, Massachusetts


Ann Intern Med. 1982;97(4):608-611. doi:10.7326/0003-4819-97-4-608
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For many years it has been recognized that staphylococcal infections occasionally are accompanied by evidence of toxemia, a scarlatiniform rash and subsequent desquamation. This syndrome has been called staphylococcal scarlet fever (1, 2). During the past few years, however, this clinical pattern has emerged from relative obscurity to become notorious as a consequence of two groups of events: the restatement of the syndrome in modern terms (3) along with a series of dramatic cases and a catchy title, toxic shock syndrome, and the recognition by several infectious disease physicians and epidemiologists in Minnesota and Wisconsin that the syndrome was particularly

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