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Factor VIII Activity and Thyroid Function

JOHN S. ROGERS II, M.D.; STANLEY R. SHANE, M.D.; and FRANCES S. JENCKS, M.T.
[+] Article and Author Information

Grant support: in part by Biomedical Research Support Grant 5S07 RR05433 and by the West Virginia University Medical Corporation.

▸Requests for reprints should be addressed to John S. Rogers II, M.D.; Department of Medicine, Section of Hematology/Oncology, West Virginia University Medical Center; Morgantown, WV 26506.


Morgantown, West Virginia


© 1982 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1982;97(5):713-716. doi:10.7326/0003-4819-97-5-713
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Plasma factor VIII coagulant activity is decreased in hypothyroid patients and increased in hyperthyroid patients. We studied 21 untreated hypothyroid patients. Factor VIII coagulant activity was mildly decreased in association with significant depression of factor-VIII-related antigen and ristocetin cofactor activity in five patients. Factor-VIII-related properties significantly increased with oral thyroid replacement therapy in seven of 10 patients. Twenty-two untreated hyperthyroid patients were similarly evaluated. In 21 of these patients significant increases were noted in factor VIII coagulant activity, factor-VIII-related antigen, and ristocetin cofactor activity. Elevated factor-VIII-related properties returned to normal in all of 10 patients treated with radioactive iodine or propylthiouracil. We discuss the relation between thyroid function and factor-VIII-related properties in both hypothyroid and hyperthyroid patients.

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