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Increased Incidence of Acute Promyelocytic Leukemia in Patients with Ulcerative Colitis

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▸Requests for reprints should be addressed to Janet Cuttner, M.D.; The Mount Sinai Hospital, Hematology Division, 100 Street at Madison Avenue; New York, NY 10029.

Polly Annenberg Levee Hematology Center, The Mount Sinai Hospital; New York, New York.

Ann Intern Med. 1982;97(6):864-865. doi:10.7326/0003-4819-97-6-864
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Ulcerative colitis is an inflammatory disease of unknown origin. Immune mechanisms are now considered important in the etiology of this disease (1-3). Recognized hematologic complications in this disorder include iron deficiency anemia related to bleeding, and Coombs' positive hemolytic anemia associated with the drug salicylazosulfapyridine (Azulfidine, Pharmacia Laboratories, Piscataway, New Jersey). Thrombocytosis and leukocytosis can occur in the active phase of the disease. We report six patients with a long-standing history of ulcerative colitis who developed acute leukemia; five cases of which were of a specific subtype, acute promyelocytic leukemia.

From 1974 through 1981, 227 patients newly diagnosed as having


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