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Unstable Angina: Guidelines for Therapy Based on the Last Decade of Clinical Observations

B. GREG BROWN, M.D., PH.D.; and HAROLD T. DODGE, M.D.
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University of Washington School of Medicine; Seattle, Washington


Ann Intern Med. 1982;97(6):921-923. doi:10.7326/0003-4819-97-6-921
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The prognosis and best therapy for unstable angina, a diagnostic label that has been applied to a spectrum of clinical presentations in patients with (and without) coronary disease, have been controversial. The problem developed because of the heterogeneity of patient selection and the variety of diagnostic and therapeutic options. In 1972, the Unstable Angina Pectoris Study Group, sponsored by the National Heart, Lung, and Blood Institute, set out to evaluate objectively the types of therapy (1). The Group's definition of unstable angina was narrow enough to exclude most patients with noncardiac causes of chest pain and yet broad enough to

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