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Wegener's Granulomatosis: Prospective Clinical and Therapeutic Experience With 85 Patients for 21 Years

ANTHONY S. FAUCI, M.D.; BARTON F. HAYNES, M.D.; PAUL KATZ, M.D.; and SHELDON M. WOLFF, M.D.
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▸Requests for reprints should be addressed to Anthony S. Fauci, M.D.; Building 10, Room 11B-13, National Institutes of Health; Bethesda, MD 20205.


Bethesda, Maryland


©1983 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1983;98(1):76-85. doi:10.7326/0003-4819-98-1-76
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Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health. Patients were treated with a protocol consisting of cyclophosphamide, 2 mg/kg body weight · d, together with prednisone, 1 mg/kg body weight · d, followed by conversion of the prednisone to an alternate-day regimen. Complete remissions were achieved in 79 of 85 patients (93%). The mean duration of remission for living patients was 48.2 (± 3.6) months. Twenty-three patients are off all therapy for a mean duration of 35.3 (± 6.3) months without therapy. This study provides a prospective experience with Wegener's granulomatosis and shows that long-term remissions can be induced and maintained in an extremely high number of patients by the combination of daily cyclophosphamide and alternate-day prednisone therapy.

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