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The Human T-cell Leukemia/Lymphoma Virus, Lymphoma, Lytic Bone Lesions, and Hypercalcemia

DOUGLAS W. BLAYNEY, M.D.; ELAINE S. JAFFE, M.D.; RICHARD I. FISHER, M.D.; GERALDINE P. SCHECHTER, M.D.; JEFFREY COSSMAN, M.D.; MARJORIE ROBERT-GUROFF, Ph.D.; V. S. KALYANARAMAN, Ph.D.; WILLIAM A. BLATTNER, M.D.; and ROBERT C. GALLO, M.D.
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▸Requests for reprints should be addressed to Douglas W. Blayney, M.D.; Landow Building, Room 4C18, National Institutes of Health; Bethesda, MD 20205.


Bethesda, Maryland; Washington, D.C.; and Kensington, Maryland


Ann Intern Med. 1983;98(2):144-151. doi:10.7326/0003-4819-98-2-144
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The human T-cell lymphoma (HTL) virus is a type C RNA tumor virus isolated from patients with malignancies of mature T cells. We report three patients with peripheral T-cell lymphoma, hypercalcemia, and antibodies to HTL virus. One patient presented with idiopathic hypercalcemia of 6 months' duration, two with striking lytic bone lesions, and two with circulating malignant lymphocytes. Malignant cells from all patients had surface markers characteristic of thymic-derived lymphocytes (T cells), and all patients had natural serum antibodies to disrupted HTL virus and to one or both viral structural proteins p19 and p24. Patients with adult peripheral T-cell lymphomas, particularly those that present with hypercalcemia and lytic bone lesions, may have antibodies to the type C RNA human tumor virus, HTL virus.

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