0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Cardiovascular Changes After Weight Reduction in Obesity Hypertension

EFRAIN REISIN, M. D.; EDWARD D. FROHLICH, M.D.; FRANZ H. MESSERLI, M.D.; GERALD R. DRESLINSKI, M.D.; FRANCIS G. DUNN, M.D.; MARTHA M. JONES, B.S., R.D.; and HUGH M. BATSON Jr., M.D.
[+] Article and Author Information

Grant support: in part by a grant-in-aid HL-22506, National Heart, Lung, and Blood Institute; and from a bequest from Helen Wells Andress through the Alton Ochsner Medical Foundation.

▸Requests for reprints should be addressed to Efrain Reisin, M.D.; Ochsner Medical Foundation, 1516 Jefferson Highway; New Orleans, LA 70121.


New Orleans, Louisiana


© 1983 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1983;98(3):315-319. doi:10.7326/0003-4819-98-3-315
Text Size: A A A

Intravascular volumes and systemic and regional hemodynamic variables were measured before and after weight reduction in 12 patients with obesity and essential hypertension. These findings were compared with those in nine patients who did not have any weight loss. Reduction of mean arterial pressure significantly correlated with the fall in total body weight (r= 0.46, p < 0.05). Total circulating and cardiopulmonary blood volumes were significantly reduced (p < 0.05 and p < 0.01, respectively), and these changes permitted a decreased venous return and cardiac output (p < 0.01). This fall in cardiac output was directly related to a contracted total blood volume (r=0.49,p < 0.05) and decreased cardiopulmonary blood volume (r= 0.52, p < 0.05). Patients who did not lose weight showed no changes in any of these hemodynamic measurements. In addition, weight loss was associated with reduced resting circulating levels of plasma norepinephrine (p < 0.01), suggesting that diminished adrenergic function may also be related to weight reduction and its associated fall in arterial pressure.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)