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Severe Depression of Antithrombin III Associated with Disseminated Intravascular Coagulation in Women with Fatty Liver of Pregnancy

HOWARD A. LIEBMAN, M.D.; WILLIAM G. MCGEHEE, M.D.; MARY JANE PATCH, B.A.; and DONALD I. FEINSTEIN, M.D.
[+] Article and Author Information

Grant support: in part by grant 5R CA 24426-01, National Cancer Institute.

Presented in part 18 August 1980, at the 18th Congress of the International Society of Hematology, Montreal, Canada.

▸Requests for reprints should be addressed to William G. McGehee, M.D.; Hematology Division, USC School of Medicine, 2025 Zonal Avenue; Los Angeles, CA 90033.


Los Angeles, California


© 1983 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1983;98(3):330-333. doi:10.7326/0003-4819-98-3-330
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Serial coagulation studies were done in four women with acute fatty liver of pregnancy. All had coagulopathy, laboratory evidence of diffuse intravascular coagulation, and marked depletion of plasma antithrombin III. Two of these women had persistent intravascular coagulation for 4 days after delivery. The others had prompt control of intravascular coagulation coincident with elevation of the antithrombin III concentration by plasma transfusion. Severe antithrombin III depression may be a major cause of the persistent intravascular clotting and can be corrected by plasma transfusion.

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