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Hyponatremia in Rocky Mountain Spotted Fever: Role of Antidiuretic Hormone

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▸Requests for reprints should be addressed to Lisa Kaplowitz, M.D.; Department of Medicine, Medical College of Virginia, Box 102, MCV Station; Richmond, VA 23298.

University of North Carolina; Chapel Hill, North Carolina; and the University of Chicago; Chicago, Illinois

Ann Intern Med. 1983;98(3):334-335. doi:10.7326/0003-4819-98-3-334
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Rocky Mountain spotted fever is a systemic vasculitis caused by the invasion of vascular endothelial cells by Rickettsia rickettsii. Increased vascular permeability occurs because of endothelial injury often resulting in decreased intravascular volume, hypotension, and in some patients, edema. In its more advanced stages the disease frequently involves several organ systems.

Although hyponatremia has been reported widely in Rocky Mountain spotted fever, occurring in over 50% of patients in some series, its mechanism is not known (2). In our study antidiuretic hormone (ADH) levels were elevated relative to plasma hypo-osmolality in four patients with Rocky Mountain spotted fever and hyponatremia.


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