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Acute Non-Lymphoblastic Leukemia After Treatment of Nodular Lymphoma with Human Leukocyte Interferon

RAYMOND P. WARRELL Jr., M.D.; SUSAN E. KROWN, M.D.; BENJAMIN KOZINER, M.D.; MICHAEL ANDREEFF, M.D.; and SANFORD J. KEMPIN, M.D.
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Grant support: in part by grant CH-154 and a Junior Faculty Clinical Fellowship Award to Dr. Warrell from the American Cancer Society.

▸Requests for reprints should be addressed to Raymond P. Warrell, Jr., M.D.; Memorial Sloan-Kettering Cancer Center, 1275 York Avenue; New York, NY 10021.


Memorial Sloan Kettering Cancer Center; and the Cornell University Medical College; New York, New York


Ann Intern Med. 1983;98(4):482-483. doi:10.7326/0003-4819-98-4-482
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There has been an increase in the incidence of acute non-lymphoblastic leukemia after the use of radiation or cytotoxic chemotherapy in patients with malignant lymphoma. However, the subsequent occurrence of this disease in patients with nodular lymphocytic lymphoma who have never received radiation or chemotherapy has not been reported previously. We report a case of acute non-lymphoblastic leukemia which has occurred in a patient with nodular lymphoma whose only previous treatment had consisted of leukocyte interferon.

A 57-year-old man developed diffuse lymphadenopathy in September 1979. An excisional biopsy showed a malignant lymphoma of the nodular poorly differentiated lymphocytic type. A

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