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Anomalous Serum Digoxin Concentrations in Uremia

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▸Requests for reprints should be addressed to Dr. Roland Valdes, Jr.; Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, 215 S. Kingshighway, P.O. Box 14109; St. Louis, MO 63178.

The Jewish Hospital of St. Louis and Washington University School of Medicine; St. Louis, Missouri

Ann Intern Med. 1983;98(4):483-484. doi:10.7326/0003-4819-98-4-483
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When digoxin therapy is discontinued, it is generally assumed that the patient's serum concentration of the drug will decrease over time with a half-life dependent on the rate of digoxin elimination. A few reports (1, 2) have noted deviations from this prediction. We describe a patient with acute renal failure who had an unanticipated twofold rise in his apparent serum concentration of digoxin during the 9 days after the last administered dose of this drug.

A 56-year-old black man with hypertension was hospitalized for atrial fibrillation complicated by embolic small bowel infarction. Several surgical procedures prolonged his hospitalization. An intravenous



digoxin ; uremia

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