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Anomalous Serum Digoxin Concentrations in Uremia

JEFFREY L. CRAVER, M.D.; and ROLAND VALDES Jr., Ph.D.
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▸Requests for reprints should be addressed to Dr. Roland Valdes, Jr.; Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, 215 S. Kingshighway, P.O. Box 14109; St. Louis, MO 63178.


The Jewish Hospital of St. Louis and Washington University School of Medicine; St. Louis, Missouri


Ann Intern Med. 1983;98(4):483-484. doi:10.7326/0003-4819-98-4-483
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This excerpt has been provided in the absence of an abstract.

When digoxin therapy is discontinued, it is generally assumed that the patient's serum concentration of the drug will decrease over time with a half-life dependent on the rate of digoxin elimination. A few reports (1, 2) have noted deviations from this prediction. We describe a patient with acute renal failure who had an unanticipated twofold rise in his apparent serum concentration of digoxin during the 9 days after the last administered dose of this drug.

A 56-year-old black man with hypertension was hospitalized for atrial fibrillation complicated by embolic small bowel infarction. Several surgical procedures prolonged his hospitalization. An intravenous

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Topics

digoxin ; uremia

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