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Sodium and Blood Pressure |

Volume Hormones and Blood Pressure

JACQUES GENEST, M. D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Jacques Genest, MD.; Clinical Research Institute of Montreal, 110 Pine Avenue, West; Montreal, Quebec PQ H2W 1R7, Canada.


Montreal, Quebec, Canada


© 1983 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1983;98(5_Part_2):744-749. doi:10.7326/0003-4819-98-5-744
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Four major volume hormones may be involved in human hypertension: aldosterone, arginine vasopressin, inhibitors of NA+/K+ ATPase activity, and the natriuretic factor from specific granules of atrial cardiocytes. Because there is no increase in either blood or extracellular fluid volumes, or total exchangeable sodium in patients with mild essential hypertension, the mechanism of action of the volume hormones must be through their effect on sodium regulation, intracellular concentration, and the related enhancement of arteriolar sensitivity and responsiveness. A review of the evidence relating these hormones to blood pressure regulation emphasizes inhibitors of Na+/K+ ATPase activity, and the potent natriuretic and diuretic factor found in homogenates of rat atria.

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