0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Intravenous Acyclovir for the Treatment of Primary Genital Herpes

LAWRENCE COREY, M.D.; KENNETH H. FIFE, M.D., Ph.D.; JACQUELINE K. BENEDETTI, Ph.D.; CAROL A. WINTER, R.N.; ANITA FAHNLANDER, R.N.; JAMES D. CONNOR, M.D.; MARIE A. HINTZ, M.D.; and KING K. HOLMES, M.D., Ph.D.
[+] Article and Author Information

Grant support: in part by grant AI-14495 from the National Institutes of Health, training grant AI-07044 to Dr. Fife from the National Institutes of Health, grant RR-37 to the General Clinical Research Center from the National Institutes of Health, and a grant from the Burroughs Wellcome Co.

▸Requests for reprints should be addressed to Lawrence Corey, M.D.; Virology Laboratory, Children's Orthopedic Hospital Medical Center, P.O. Box C5371, 4800 Sand Point Way NE; Seattle, WA 98105.


Ann Intern Med. 1983;98(6):914-921. doi:10.7326/0003-4819-98-6-914
Text Size: A A A

Thirty-one patients with first episodes of genital herpes were randomized in a double-blind fashion to intravenous treatment with saline placebo or acyclovir, 5 mg/kg body weight at 8-hour intervals, for 5 days. The median duration of viral shedding from genital lesions after the onset of therapy was significantly shorter for patients given acyclovir (2 days) than for those given placebo (13 days), p < 0.001. Viral shedding from the pharynx, cervix, urethra, and urine were also shorter in acyclovir-treated patients. (p < 0.01 for each comparison). Local and systemic symptoms were shortened by a mean of 5 days and healing of genital lesions by a mean of 12 days in acyclovir-treated patients. (p < 0.01). Complications during treatment, such as extragenital lesions or urinary retention requiring catheterization, developed in four patients given placebo and in none given acyclovir. (p < 0.05). Intravenous acyclovir substantially decreases the symptoms, duration of lesions, and complications of primary genital herpes.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Mother-to-Child Transmission of Herpes Simplex Virus. J Pediatric Infect Dis Soc 2014;3(Suppl 1):S19-S23.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)