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Serum Antibodies Against Mouse Mammary Tumor-Virus-Associated Antigen Detected Nine Months Before Appearance of a Breast Carcinoma

MAN-CHlU POON, M. D.; MILAN TOMANA, Ph.D; and WILLIAM NIEDERMEIER, Ph.D.
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▸Requests for reprints should be addressed to Man-Chiu Poon, M.D.; Division of Hematology/Oncology, Department of Medicine, University of Alabama in Birmingham, University Station; Birmingham, AL 3S294.


University of Alabama, and the Birmingham Veterans Administration Medical Center; Birmingham, Alabama


Ann Intern Med. 1983;98(6):937-938. doi:10.7326/0003-4819-98-6-937
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Earlier investigations (1-4) showed an immunologic relation between human breast cancer and mouse mammary tumor virus (MMTV). The presence of antibodies in sera of patients with breast cancer reacting with antigens in the cytoplasm of mouse mammary tumor cells was shown by various methods including indirect immunofluorescence (5). This reactivity could be abolished by absorption of the sera with MMTV (5, 6) or intracytoplasmic type A particles (7). The specificity of the reactivity of human antibodies with MMTV-associated antigens has been questioned by some investigators (8). Our patient's serum, initially nonreactive with MMTV-associated antigens, became reactive 9 months before the

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