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Peritoneal Dialysis for Psoriasis: A Controlled Study

FREDERICK C. WHITTIER, M.D.; DAN H. EVANS, M.D.; PHILIP C. ANDERSON, M.D.; and KARL D. NOLPH, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Frederick C. Whittier, M.D.; West Virginia University Medical Center, Department of Internal Medicine; Morgantown, WV 26506.


Columbia, Missouri


© 1983 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1983;99(2):165-168. doi:10.7326/0003-4819-99-2-165
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Sham and real trials of peritoneal dialysis were carried out in a double-blind crossover study design to test the efficacy of peritoneal dialysis as a treatment for psoriasis. The criteria for patients included having severe plaquetype psoriasis unresponsive to all conventional therapy including methotrexate. Patients were randomly assigned to 4 weeks of sham or real dialysis, 8 weeks of observation, 4 weeks of alternative real or sham dialysis and 8 weeks of observation. Topical therapy was continued during the trial. Real dialysis was done for 48 hours weekly with 1.5-hour cycle times and 2-litre exchanges by machine. Sham peritoneal dialysis was done recycling the same 2 litres of 1.5% continuous ambulatory peritoneal dialysis fluid with 1.5-hour cycle times for 48 hours weekly. After real dialysis, two patients completely cleared, two patients had greater than 75% clearing, and one patient had no substantial response. None of the five patients had a response to the sham dialysis procedure (p < 0.01).

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