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Combination Chemotherapy for Malignant Thymoma

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▸Send reprint request to Gedske Daugaard, M.D., Department of Chemotherapy, Finsen Institute, Strandboulevarden 49; DK-2100 Copenhagen Ø, Denmark.

Finsen Institute; Copenhagen,Denmark

Ann Intern Med. 1983;99(2):189-190. doi:10.7326/0003-4819-99-2-189
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Surgery and radiotherapy have been considered as the primary therapies for malignant thymoma. Recent information on chemotherapy (1-4) and steroidal therapy (5) indicates that invasive thymomas are sensitive to cytostatic agents. Most of the evidence has been presented only in single case reports; we discuss our experience with nine patients.

From 1975 to 1982, nine patients with malignant thymoma (histologically classified as thymoma with invasive features at primary surgery) were treated with the same type of combination chemotherapy at the Department of Chemotherapy, Finsen Institute. Thoracotomy was initially done in six patients, sterniotomy in two, and mediastinoscopy in one patient.


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