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Making Intensified Insulin Treatment Safer

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Temple University Hospital, Philadelphia, Pennsylvania

Ann Intern Med. 1983;99(2):268-269. doi:10.7326/0003-4819-99-2-268
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Intensified insulin regimens with continuous subcutaneous infusion by portable pumps or by multiple insulin injections in combination with home glucose monitoring have made the maintenance of near normal blood glucose levels a therapeutic reality. Both methods are presently being practiced by an increasing number of diabetic patients in hopes of delaying or preventing acute or chronic diabetic complications. Not unexpectedly these aggressive insulin regimens have resulted in frequent hypoglycemia in many patients. Moreover, several unexpected deaths, some probably related to hypoglycemia, have been reported in patients using insulin infusion pumps. As a result, the Centers for Disease Control issued a




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