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Statistical Power Analysis in Medical Research

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423 Vine Street; Philadelphia, Pennsylvania

Ann Intern Med. 1983;99(2):269-271. doi:10.7326/0003-4819-99-2-269
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Many clinicians and medical researchers are unsure how to interpret data that do not pass tests of statistical significance. Because a nonsignificant result does not imply that there is no effect or no difference, it is important to make "the distinction between positively demonstrating that a treatment had no effect and failing to demonstrate that it does have an effect . . ." (1). In clinical trials, the lack of efficacy of a new treatment sometimes is inferred from a nonsignificant difference between outcomes in treatment and placebo groups. Such inferences are invalid without consideration of the ability of the


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