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Selected Methods for the Management of Diabetes Mellitus

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Grant support: The Clinical Efficacy Assessment Project is funded by the John A. Hartford Foundation.

© 1983 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1983;99(2):272-274. doi:10.7326/0003-4819-99-2-272
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The goal of management of diabetes mellitus includes the achievement of normalization or near-normalization of a variety of metabolic variables, of which the blood glucose level is one component. There is controversy about the value of euglycemic control or near-control of blood glucose levels (fasting and preprandially, 70 to 120 mg/dL; 2-h postprandially, <180 mg/dL; 0300 h, >60 mg/dL). Such control may be achieved through intensive measurement of blood glucose levels and daily multiple injections of insulin done by the patient under a physician's supervision. A large number of animal studies and a few clinical observations in humans suggest that


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