0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Multiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome

RANDALL C. BELL, M.D.; JACQUELINE J. COALSON, Ph.D.; JAN D. SMITH, M.B.; and W. G. JOHANSON Jr., M.D.
[+] Article and Author Information

Grant support: in part by grant HL-23578 from the National Heart, Lung and Blood Institute, and by the General Medical Research Service of the Veterans Administration Hospital. This work was completed during Dr. Bell's tenure as a Parker B. Francis Foundation Fellow.

▸Requests for reprints should be addressed to Randall C. Bell, M.D.; Pulmonary Disease Section, IIIE, Audie L. Murphy Memorial Veterans Hospital, 7400 Merton Miner Boulevard, San Antonio, TX 78284.


San Antonio, Texas


© 1983 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1983;99(3):293-298. doi:10.7326/0003-4819-99-3-293
Text Size: A A A

Patients with the adult respiratory distress syndrome and multiple organ system failure have a high mortality rate despite extensive supportive therapy. We evaluated the role of multiple organ system failure and infection in 37 consecutive survivors of the syndrome, and 47 consecutive nonsurvivors on whom autopsies were done. Failure of the central nervous, coagulation, endocrine, gastrointestinal, and renal systems was common in all patients but was more frequent in those who died. Major infections occurred in 46 nonsurvivors and 22 survivors. All patients with bacteremia who had a clinically identified site of infection survived, whereas all patients with bacteremia without a clinically identified site of infection died. Autopsy results of the latter group showed infections requiring surgical drainage for complete therapy. Patients clinically septic but without bacteremia and without a clear site of infection were shown at autopsy to have pneumonia. Multiple organ system failure was more common in infected (93%) than noninfected (47%) patients. Vigorous evaluation and treatment of infection in patients with the adult respiratory distress syndrome may improve survival.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)