The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Reports |

Hairy Cell Leukemia: A Five-Year Update on Seventy-One Patients

[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to Harvey M. Golomb, M.D.; University of Chicago, 950 East 59th Street, Box 420; Chicago, IL 60637.

University of Chicago Hospitals and Clinics, Chicago, Illinois; Royal Postgraduate Medical School, London, England; UCLA School of Medicine, Los Angeles, California

Ann Intern Med. 1983;99(4):485-486. doi:10.7326/0003-4819-99-4-485
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Hairy cell leukemia, although rare, has become a well-described clinicopathologic entity since its identification in 1958 (1). Patients with the disease have circulating leukemic cells with prominent cytoplasmic projections. These cells are tartrate-resistant acid-phosphatase-positive in cytochemical tests. These cytochemical features, combined with a characteristic pattern of bone marrow involvement, are diagnostic for hairy cell leukemia (2, 3). Clinically, most patients have splenomegaly without adenopathy. Usually, a pancytopenia is present, but 10% to 20% of patients have an elevated leukocyte count, most of these leukocytes being hairy cells (4, 5).

Splenectomy has been recommended as the initial treatment when therapy is


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.