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Ranitidine or Cimetidine

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Veterans Administration Medical Center, Albuquerque, New Mexico

Ann Intern Med. 1983;99(4):551-553. doi:10.7326/0003-4819-99-4-551
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Physicians in the United States are now getting their first experience with ranitidine HCL (Zantac; Glaxo Inc., Fort Lauderdale, Florida), a new H2-receptor blocking antihistamine that inhibits gastric acid secretion with a potency four- to eightfold that of cimetidine (1, 2). In June, the FDA approved marketing of the drug for short-term oral use in the treatment of duodenal ulcer and for unrestricted use in hypersecretory states, such as the Zollinger-Ellison syndrome. The drug is not yet approved for gastric ulcer, maintenance therapy in duodenal ulcers, or parenteral use. Ranitidine received a therapeutic rating of 1C, which the FDA assigns


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