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Acquired Factor XIII Deficiency with Chronic Myelomonocytic Leukemia

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▸Requests for reprints should be addressed to Leonard Ellman, M.D.; Massachusetts General Hospital, Ambulatory Care Center, Room 436, 15 Parkman Street; Boston, MA 02114.

Massachusetts General Hospital; Boston, Massachusetts.

Ann Intern Med. 1983;99(5):638-639. doi:10.7326/0003-4819-99-5-638
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Acquired factor XIII deficiency is a rare disorder that leads to spontaneous bleeding and large hematomas. Most cases have occurred in the setting of isoniazid therapy. We report a case of acquired factor XIII deficiency in the setting of chronic myelomonocytic leukemia.

An 80-year-old white woman was admitted to the hospital in June 1981 with symptoms of fatigue and weight loss. The spleen was palpable on inspiration. The hematocrit was 36%, the leukocyte count was 73 000/mm3 with a differential of 56% polymorphonuclear leucocytes, 5% bands, 6% lymphocytes, 21% monocytes, 1% eosinophil, 1% basophils, 15% blast forms, 1% myelocytes and


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