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Recent Developments in Pulmonary Edema

EDWARD D. CRANDALL, Ph.D., M.D.; NORMAN C. STAUB, M.D.; HOWARD S. GOLDBERG, M.D.; and RICHARD M. EFFROS, M.D.
[+] Article and Author Information

Grant support: by grants HL26223 and HL18606 from the U. S. Public Health Service; and by grant IG-738 from the Greater Los Angeles Affiliate of the American Heart Association. Dr. Goldberg's research supported by funds from the Irvine Foundation, Sidney Stern Memorial Trust, and the Herzog Family Trust.

▸Requests for reprints should be addressed to Edward D. Crandall, Ph.D., M.D.; Department of Medicine, Division of Pulmonary Disease, UCLA School of Medicine; Los Angeles, CA 90024.


Los Angeles and San Francisco, California


©1983 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1983;99(6):808-822. doi:10.7326/0003-4819-99-6-808
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Research on lung fluid balance and pulmonary edema has increased during the last decade. New approaches have led to insights into the role of each component of the alveolar-capillary barrier. The capillary endothelium is the first line of defense against lung fluid accumulation. The interstitium may play a more important role in lung fluid balance than previously appreciated. Active and passive transport properties of alveolar epithelium may be important in the pathogenesis and resolution of alveolar edema. New methods for the determination of epithelial permeability and lung water are being evaluated. The developments reviewed here may have an impact on the institution of new diagnostic and therapeutic approaches to pulmonary edema during the next decade.

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