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Cyclosporine Nephrotoxicity

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Oregon Health Sciences University; Portland, Oregon

Ann Intern Med. 1983;99(6):851-854. doi:10.7326/0003-4819-99-6-851
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Cyclosporine is a potent new immunosuppressive agent that selectively inhibits T-cell function, allowing survival of allografts without myelosuppression. Its use should minimize the many adverse effects of long-term steroid therapy. Although the long-term effects of cyclosporine on renal allograft longevity are not well documented, enthusiastic reports in the medical literature and lay press have led to an unprecedented anticipation by prospective allograft recipients, particularly patients with chronic renal failure receiving long-term dialysis. However, these reports have not sufficiently emphasized the nephrotoxicity that frequently accompanies cyclosporine therapy.

Cyclosporine is a lipophilic molecule with a molecular weight of 1202 daltons. When the


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