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Percutaneous Transluminal Angioplasty

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Grant support: The Clinical Efficacy Assessment Project is funded by the John A. Hartford Foundation.

Quotations in advertisements and other commercial publications of text in the American College of Physicians position papers and Clinical Efficacy Assessment Project recommendations must be with express permission from the Department of Health and Public Policy, American College of Physicians, 4200 Pine Street, Philadelphia, PA 19104.

▸Requests for reprints should be sent to Linda Johnson White; Clinical Efficacy Assessment Project, Department of Health and Public Policy, American College of Physicians, 4200 Pine Street; Philadelphia, PA 19104.

©1983 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1983;99(6):864-869. doi:10.7326/0003-4819-99-6-864
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Percutaneous transluminal angioplasty involves passage of a balloon-tipped catheter to the site of arterial narrowing and inflation of the balloon to reduce the obstruction. This technique is always done in conjunction with angiography of the vessel to be treated. Successful percutaneous transluminal angioplasty results in a reduction of the arterial stenosis and a decrease in the trans-stenotic pressure gradient (1, 2). The mechanisms of action are not known completely but are thought to involve compression of atherosclerotic plaque, disruption and splitting of the plaque and the intima and media of the artery, and stretching of the arterial wall (2-7). Some


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