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Hodgkin's Disease in Patients Over Sixty Years Old

MARY M. AUSTIN-SEYMOUR, M.D.; RICHARD T. HOPPE, M.D.; RICHARD S. COX, Ph.D.; SAUL A. ROSENBERG, M.D.; and HENRY S. KAPLAN, M.D.
[+] Article and Author Information

Grant support: in part by an American Cancer Society Regular Clinical Fellowship, and by Grant CA 34233 from the National Cancer Institute, National Institutes of Health.

Presented in part in May 1983 at the Annual Meeting of the American Society of Clinical Oncology; San Diego, California.

▸Requests for reprints should be addressed to Mary M. Austin-Seymour; M.D.; Lawrence Berkeley Laboratory, 1 Cyclotron Road, Building 55; Berkeley, CA 94720.


Stanford, California


© 1984 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1984;100(1):13-18. doi:10.7326/0003-4819-100-1-13
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Fifty-two patients 60 to 75 years of age were treated for Hodgkin's disease at Stanford University between 1968 and 1980. Adequate staging was defined as including a lymphogram and staging laparotomy for stage I to III and a positive bone marrow or liver biopsy or other evidence of diffuse involvement of extralymphatic tissues for stage IV. Adequate treatment was defined as subtotal lymphoid irradiation for pathologic stages I to MA; total lymphoid irradiation for stages IIB to IIIA; and chemotherapy with or without irradiation for stages IIIB to IV. Twenty-four patients (46%) had advanced disease (IIIB to IV). Those patients who received appropriate treatment had a median survival of only 39 months. Of the 28 patients with limited disease (I to IIIA), 15 had laparotomy and adequate treatment. Thirteen did not have a laparotomy and 7 were treated with involved-field irradiation. The 5-year survival rate in the laparotomy-staged and adequately treated group was 86%, but in the clinically staged group, only 35% (p = 0.006).

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