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Vitamin D Conversion by Sarcoid Lymph Node Homogenate

REBECCA S. MASON, M.B., Ph.D.; THERESA FRANKEL, B.V.Sc., Ph.D.; YUK-LUEN CHAN, M.B.; DIANNE LISSNER; and SOLOMON POSEN, M.D.
[+] Article and Author Information

Grant support: The National Health and Medical Research Council of Australia, the New South Wales State Cancer Council, and the Coppleson Postgraduate Foundation of the University of Sydney.

Presented in part June 1983 at the Fifth Annual Scientific Meeting of the American Society for Bone and Mineral Research, San Antonio, Texas.

▸Requests for reprints should be addressed to Solomon Posen, M.D.; Endocrine Unit, Royal North Shore Hospital; St. Leonards, N.S.W., 2065, Australia.


St. Leonards, Australia


© 1984 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1984;100(1):59-61. doi:10.7326/0003-4819-100-1-59
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Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from calcitriol, whereas six nonsarcoid lymph nodes failed to produce this compound.

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