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Late Recurrence of Minimal Lesion Nephrotic Syndrome

CESAR PRU, M.D.; CARL M. KJELLSTRAND, M.D.; RICHARD A. COHN, M.D.; and ROBERT L. VERNIER, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Robert L. Vernier, M.D.; Department of Pediatrics, Box 491 Mayo Building, University of Minnesota, 420 Delaware Street S.E.; Minneapolis, MN 55455.


Minneapolis, Minnesota


© 1984 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1984;100(1):69-72. doi:10.7326/0003-4819-100-1-69
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Nephrotic syndrome recurred in 16 patients who had been free of the disease for an interval of 4 to 25 years. Their initial illness began in childhood and responsed to adrenocorticosteroid therapy; in 10 patients it was associated with few changes on light microscopic examination of kidney biopsy specimens. The late recurrence also responded to steroids, and in only 1 patient did low-grade proteinuria persist after treatment. Renal biopsy specimens taken from 8 patients during late recurrence showed minimal-change nephrotic syndrome in 7 and focal segmental glomerulosclerosis in 1. Renal function remained normal in all patients. The late recurrence of minimal-change nephrotic syndrome has most of the features of that syndrome seen in the more typical childhood age group and should be managed similarly.

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