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Prednisone Therapy of Post-Transfusion Purpura

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▸Requests for reprints should be addressed to Charles A. Linker, M.D.; University of California, San Francisco, 400 Parnassus Avenue A-502; San Francisco, CA 94143.

University of California, San Francisco; San Francisco, California.

Ann Intern Med. 1984;100(1):76-77. doi:10.7326/0003-4819-100-1-76
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Post-transfusion purpura is a rare syndrome characterized by sudden, severe thrombocytopenia occurring 1 week after a blood transfusion (1). Although most patients have had mild bleeding and recovered spontaneously, some have died from bleeding complications (2). Plasmapheresis and exchange transfusion have resulted in clinical improvement in some cases (3), but other less invasive treatments have failed to produce clear-cut responses (4). We report the case of a patient with post-transfusion purpura in whom prednisone therapy led to a rapid, complete response.

A 59-year-old woman with a history of transfusions and three pregnancies had revision of a hip replacement. There was


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