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Zinc Supplementation and Growth in Sickle Cell Disease

[+] Article, Author, and Disclosure Information

Grant support: In part by a grant from the Sickle Cell Center of the National Heart, Lung and Blood Institute; by grant AM31401-01 from the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases; and a grant from the Veterans Administration.

Presented in part at the Annual Meeting of the Association of American Physicians, Washington, D.C., 8-10 May 1982.

▸Requests for reprints should be addressed to Ananda S. Prasad, M.D., Ph.D.; Special Hematology/Newberry Hall, Harper-Grace Hospitals, 3990 John R.; Detroit, MI 48201.

Detroit and Allen Park, Michigan

© 1984 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1984;100(3):367-371. doi:10.7326/0003-4819-100-3-367
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With the use of flameless atomic absorption spectrophotometry, we have devised a technique for measuring zinc in neutrophils. Neutrophil zinc levels in patients with sickle cell anemia correlated significantly with height and weight, and with serum testosterone in men. Such correlations were not seen with zinc levels in plasma or erythrocytes. We also report the beneficial effects of zinc supplementation on longitudinal growth and body weight in 14- to 18-year-old patients with sickle cell anemia. Thus, the neutrophil zinc level is a reliable and sensitive indicator of zinc deficiency in these patients.





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