The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

More on Chenodiol: Continued Treatment and Prevention of Recurrences

[+] Article, Author, and Disclosure Information

Columbia University College of Physicians and Surgeons; New York, New York

Ann Intern Med. 1984;100(3):450-451. doi:10.7326/0003-4819-100-3-450
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

The results of the National Cooperative Gallstone Study reported in 1981 (1) were disappointing. After patients received chenodiol, 750 or 375 mg/d, or placebo for 2 years, complete dissolution of gallstones occurred in 13.5%, 5.2%, and 0.8%, respectively; partial dissolution (> 50%) occurred in 27.3%, 18.4%, and 10.2%. Two reasons for the poor response have been proposed (2): First, because the dose was suboptimal (as we now know) and for other reasons, bile may have been inadequately desaturated. Second, characteristics of the stones themselves may have prevented dissolution. If desaturation was inadequate, a longer period of treatment (or other measures)


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.