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Prolonged Initial Remission in Patients with Nodular Mixed Lymphoma

DAN L. LONGO, M.D.; ROBERT C. YOUNG, M.D.; SUSAN M. HUBBARD, R.N.; MARGARET WESLEY, Ph.D.; RICHARD I. FISHER, M.D.; ELAINE JAFFE, M.D.; COSTAN BERARD, M.D.; and VINCENT T. DeVITA Jr., M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Dan L. Longo, M.D.; Medicine Branch, National Cancer Institute, Building 10, Room 12N226; Bethesda, MD 20205.


Bethesda, Maryland


Ann Intern Med. 1984;100(5):651-656. doi:10.7326/0003-4819-100-5-651
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Seventy-nine patients with nodular mixed lymphoma were treated at the National Cancer Institute between 1966 and 1978. Fifteen patients had stage I or II disease, and 64, stage III or IV disease. The overall complete response rate for the patients that received various primary treatment regimens was 76%, with 52% of complete responders remaining in their first remission at a median follow-up of 7 years. Median survival of complete responders is projected to be more than 13 years. Median survival of patients who do not achieve complete remission is less than 2 years. Patients with B symptoms, bone marrow involvement, or a lactate dehydrogenase level greater than 250 U/mL had significantly shorter survivals than did patients without these features. Patients with advanced-stage (III and IV) nodular mixed lymphoma had a 72% complete response rate, with the average remission lasting more than 6 years. Although relapses have been seen up to 8 years after diagnosis in patients with nodular mixed lymphoma given C-MOPP chemotherapy (cyclophosphamide, vincristine, procarbazine, prednisone), prolonged initial remissions can be achieved with this therapy.

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