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Familial Colonic Cancer Without Antecedent Polyposis

C. RICHARD BOLAND, M.D.; and FRANK J. TRONCALE, M.D.
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Grant support: in part by PHS Grant CA 30667 from the National Cancer Institute; and the Medical Research Service of the Veterans Administration.

▸Requests for reprints should be addressed to C. Richard Boland, M.D.; Gastrointestinal Research Laboratory (151M2), Veterans Administration Medical Center, 4150 Clement Street; San Francisco, CA 94121.


Ann Intern Med. 1984;100(5):700-701. doi:10.7326/0003-4819-100-5-700
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This excerpt has been provided in the absence of an abstract.

Colorectal carcinoma is primarily caused by environmental factors (1), but a small subset of patients is unusually susceptible to colonic cancer on a familial basis and virtually all family members who inherit the critical gene can be expected to develop cancer eventually. The best known of these syndromes are familial polyposis coli and Gardner's syndrome, both easily recognizable because multiple adenomatous polyps precede the appearance of carcinoma in the colon. Less commonly recognized are the familial colonic cancer syndromes without antecedent polyposis. Such cases are important to recognize because of the serious implications for relatives of those affected.

A 38-year-old

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