The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Renal Response to Captopril in Severe Heart Failure: Role of Furosemide in Natriuresis and Reversal of Hyponatremia

[+] Article, Author, and Disclosure Information

Grant support: supported in part by grants HL 14944, HL 07236, CA 32849, and HL 05832 from the National Institutes of Health and NSG 8078 from the National Aeronautics and Space Administration, and done on a General Research Center with data analyzed by our CLINFO system supported by grant 888 from the Division of Reseach Resources, National Institutes of Health. Dr. Dzau is the recipient of an National Heart, Lung and Blood Institute Clinical Investigator Award #5-K08-00750.

▸Requests for reprints should be addressed to Victor J. Dzau, M.D.; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street; Boston, MA 02115.

© 1984 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1984;100(6):777-782. doi:10.7326/0003-4819-100-6-777
Text Size: A A A

To assess the effect of furosemide and captopril on renal function and hyponatremia in patients with severe heart failure, we studied two groups of patients with hyponatremia who were receiving digoxin therapy and whose sodium intake was 40 meq/d. One group received captopril and furosemide, the second received captopril. The first group responded to combination therapy with a brisk natriuresis and diuresis, weight reduction, and an increase in serum sodium concentration. Patients who received captopril alone did not respond, despite a similar increase in renal plasma flow and glomerular filtration rate. When furosemide was then administered to patients who had received captopril alone, a brisk natriuresis, weight loss, and correction of hyponatremia followed. Treatment with furosemide is necessary to promote natriuresis and correction of hyponatremia in patients with severe heart failure treated with captopril; the renal vascular action of captopril enhances the effectiveness of furosemide.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.