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Ethionamide-lnduced Goitrous Hypothyroidism

D. DRUCKER, M.D.; M. C. EGGO, Ph.D.; I. E. SALIT, M.D.; and G. N. BURROW, M.D.
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This paper was presented in part in May 1984 at the National Meeting of the American Association of Physicians; Washington, D.C.

▸Requests for reprints should be addressed to G.N. Burrow, M.D.; Department of Medicine, Toronto General Hospital, 101 College Street; Toronto, Ontario M5G 1L7, Canada.

Toronto, Ontario, Canada

© 1984 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1984;100(6):837-839. doi:10.7326/0003-4819-100-6-837
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A 42-year-old woman developed goitrous hypothyroidism while receiving ethionamide for treatment of an atypical mycobacterial infection. Five weeks after discontinuation of ethionamide therapy, thyroid function had returned to normal. The goitrogenic effect was studied in vitro by incubating ethionamide in various concentrations (10-3 to 10-7 mol/L) with ovine thyroid cells in tissue cultures. Ethionamide inhibited the trapping of technetium and organification of iodine at concentrations seen clinically (10-5 mol/L). Ethionamide appears to be a potential goitrogen in susceptible persons.





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