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A Non-Gastrin Secretogogue in Ulcerogenic Tumors of the Pancreas

WILLIAM Y. CHEY, M.D., D.SC.; T.-M. CHANG, Ph.D.; HYOUNG JIN PARK, M.D.; KAE YOL LEE, M.D.; ROBERT ESCOFFERY, B.SC.; YUAN FANG CHEN, M.D.; ASHOK N. SHAH, M.D.; DAVID HAMILTON, M.D.; CHUL H. YOU, M.D.; and RENE MENGUY, M.D., Ph.D.
[+] Article and Author Information

Grant support: in part by The Gennesee Hospital Gastrointestinal Research Fund, and grant AMDD #25962 from the National Institutes of Health.

▸Requests for reprints should be addressed to William Y. Chey, M.D., D.Sc.; The Genesee Hospital, 224 Alexander Street, GI Unit/WW5; Rochester, NY 14607


Rochester, New York


© 1984 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1984;101(1):7-13. doi:10.7326/0003-4819-101-1-7
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In 18 patients with hypersecretion of acid, severe ulcer diathesis, and pancreatic islet cell tumor or hyperplasia, 14 had hypergastrinemia and 4 had normal plasma gastrin concentration. The neoplasms contained several gut peptides beside gastrin. The immunoreactive gastrin in the tumor extracts measured less than 7 ng/g, less than the amount previously reported. The extracts of each patient's tumor also contained a secretogogue other than gastrin that stimulated gastric acid secretion in rats. In addition, the plasma extracts of 2 patients also contained a secretogogue that stimulated acid secretion. After surgical resection of a recurrent metastatic tumor in 1 patient, basal acid secretion decreased from 13.9 to less than 1 meq/h, and the bioactivity of the plasma disappeared. These observations suggest the existence of a secretogogue that appears to be a protein in the pancreatic tumors of some patients with severe ulcer diathesis and hypersecretion.

Topics

neoplasms ; pancreas

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