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Scurvy as an Initial Manifestation of Whipple's Disease

MARC L. BERGER, M.D.; DANIEL M. SIEGEL, M.D.; and EDWARD L. LEE, M.D.
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The University of Texas Health Science Center, and the Dallas Veterans Administration Medical Center; Dallas, Texas


Ann Intern Med. 1984;101(1):58-59. doi:10.7326/0003-4819-101-1-58
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Whipple's disease is a systemic illness that predominantly affects the gastrointestinal tract resulting in malabsorption, diarrhea, and weight loss. We report the case of a man with Whipple's disease presenting initially with cutaneous and gastrointestinal manifestations of scurvy. To our knowledge, this is the first observed association between Whipple's disease and scurvy. Endoscopic findings in scurvy have not been reported previously.

A 50-year-old white man was hospitalized for evaluation of fatigue and weakness. He had a 3-month history of anorexia, a 42-kg weight loss, intermittent burning epigastric pain, and foul-smelling diarrhea containing no overt blood, pus, or mucus. Several weeks

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