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Efficacy of Intravenous Immunoglobulin in Primary Humoral Immunodeficiency Disease

CHARLOTTE CUNNINGHAM-RUNDLES, M.D., Ph.D.; FREDERICK P. SIEGAL, M.D.; ELIZABETH M. SMITHWICK, M.D.; ALISE LION-BOULÉ, R.N.; SUSANNA CUNNINGHAM-RUNDLES, Ph.D.; JOSEPH O'MALLEY, M.D.; SILVIO BARANDUN, M.D.; and ROBERT A. GOOD, M.D., Ph.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Charlotte Cunningham-Rundles, M.D., Ph.D.; Memorial Sloan-Kettering Cancer Center, 1275 York Avenue; New York, NY 10021.


New York, New York; Sacramento, California; Washington, D.C.; Bern, Switzerland; and Oklahoma City, Oklahoma.


© 1984 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1984;101(4):435-439. doi:10.7326/0003-4819-101-4-435
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Twenty-one patients with primary humoral immunodeficiency were treated for 1 year with a chemically intact immunoglobulin, 300 mg/kg body weight given intravenously every 3 weeks, to compare immunoglobulin levels and clinical status with results achieved after standard treatment with intramuscular immunoglobulin given previously for 1 year. A substantial reduction of specific acute illnesses and antibiotic use was found for 18 of the 21 patients, particularly during the second 6 months of treatment. Average IgG levels before intravenous infusion were increased 243 mg/dL over previous intramuscular pre-injection levels. Adverse effects were recorded for 2.5% of infusions.

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