0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Recombinant Leukocyte A Interferon: An Active Agent in Advanced Cutaneous T-Cell Lymphomas

PAUL A. BUNN Jr., M.D.; KENNETH A. FOON, M.D.; DANIEL C. IHDE, M.D.; DAN L. LONGO, M.D.; JOYCE EDDY, R.N.; CHARLES F. WINKLER, M.D.; STEPHEN R. VEACH, M.D.; JACOB ZEFFREN, M.D.; STEVEN SHERWIN, M.D.; and ROBERT OLDHAM, M.D.
[+] Article and Author Information

Grant support: in part by the Department of Health and Human Services, under contract number N01-23910 with Program Resources, Inc.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views or policies of the Department of Health and Human Services, the Department of the Navy, or the Department of Defense, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

▸Requests for reprints should be addressed to Paul A. Bunn, Jr., M.D.; Head, Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue; Denver, CO 80262.


Bethesda and Frederick, Maryland; and Nutley, New Jersey


Ann Intern Med. 1984;101(4):484-487. doi:10.7326/0003-4819-101-4-484
Text Size: A A A

High-dose recombinant leukocyte A interferon (50 X 106 U/m2 body surface area, intramuscularly, three times weekly) was tested in a clinical trial involving patients with advanced cutaneous T-cell lymphomas to determine its effectiveness and toxicity. All 20 patients had advanced stages of disease refractory to two or more standard therapies. Objective partial remissions lasting 3 months to more than 25 months (median, 5 months) were documented in 9 patients. The major dose-limiting toxicity was a severe influenza-like syndrome with malaise, anorexia, depression, weight loss, and decreased performance status; this effect was reversible after dose reductions in all patients and did not recur with re-escalation of doses in 10 patients. This interferon preparation is highly effective in the treatment of advanced refractory cutaneous T-cell lymphomas, and new schedules to reduce toxicity and achieve complete responses, combined treatment with chemotherapy or serotherapy, and its use in earlier stages of disease should be investigated.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)