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Acute Lymphoblastic Leukemia in Adults

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Dana-Farber Cancer Institute, Harvard Medical School; Boston, Massachusetts

Ann Intern Med. 1984;101(4):552-554. doi:10.7326/0003-4819-101-4-552
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Considerable progress has been made during the last 20 years in the treatment of children with acute lymphoblastic leukemia. More than 90% of such patients have complete remission, and 55% to 60% of the complete responders appear to be cured after central nervous system prophylaxis and chemotherapy for 24 to 30 months after remission (1). Various clinical and laboratory features seen at the time of diagnosis have permitted the classification of children with this disease into subsets with a "standard" or "high" risk for relapse (2). Adverse features include a high leukocyte count ( > 20 000/µL), age less than


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