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Prolonged Intrahepatic Cholestasis Secondary to Acute Hepatitis A

STUART C. GORDON, M.D.; K. RAJENDER REDDY, M.D.; LEON SCHIFF, M.D., Ph.D.; and EUGENE R. SCHIFF, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Eugene R. Schiff, M.D.; Division of Hepatology, Veterans Administration Medical Center, 1201 N.W. 16th Street; Miami, FL 33125.


Miami, Florida


©1984 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1984;101(5):635-637. doi:10.7326/0003-4819-101-5-635
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Viral hepatitis characterized by prolonged cholestasis has not been associated with a specific serologic marker. We report the cases of six patients presenting with a clinical syndrome typical of cholestatic hepatitis who were subsequently found to have acute hepatitis A. Usual features include pruritus, fever, diarrhea, and weight loss with serum bilirubin levels greater than 10 mg/dL, and a clinical course lasting at least 12 weeks. All patients recovered completely without sequelae. Knowledge of this unusual manifestation of hepatitis A may help avoid potentially invasive procedures involved in the evaluation of suspected obstructive jaundice and facilitate appropriate immunoprophylactic measures.

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