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Progress in Acute Myelogenous Leukemia

Ann Intern Med. 1984;101(5):702-705. doi:10.7326/0003-4819-101-5-702
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Although leukemia is not a common disease, it has been a model for progress in modern cancer chemotherapy. Less than 30 years ago hematologists questioned whether patients with acute myelogenous leukemia should be treated (1). In the ensuing years substantial and important advances have been made, mostly within the past 10 years. Now, 60% to 80% of patients achieve a remission with intensive induction chemotherapy (1-10). Cytarabine and daunorubicin are the most effective drugs, but thioguanine, amsacrine, and high-dose cytarabine are also useful.

Once remission is achieved, the next objective is to prevent leukemic relapse; this has proved difficult. Several


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