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Clinical and Prognostic Significance of Vasculitis as an Early Manifestation of Connective Tissue Disease Syndromes

SHARAD LAKHANPAL, M.D.; DOYT L. CONN, M.D.; and J. T. LIE, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Doyt L. Conn, M.D.; Division of Rheumatology, Mayo Clinic; Rochester, MN 55905.


Rochester, Minnesota


© 1984 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1984;101(6):743-748. doi:10.7326/0003-4819-101-6-743
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The courses of 18 patients with arthritis and vasculitis in the first 2 years after onset of disease (mean follow-up, 54 months) were studied. The patients were categorized as having rheumatoid vasculitis, systemic vasculitis, and undifferentiated connective tissue syndrome. These patients cannot be distinguished on the basis of organ involvement by vasculitis or histopathologic findings on biopsy, but can be separated clinically by the extent of joint involvement and the presence or absence of rheumatoid factor and antinuclear antibody. Early onset of vasculitis is associated with a poor outcome, especially in patients with rheumatoid arthritis, with rapid progression to vasculitic involvement of the viscera, resulting in death. On the basis of the 54-month follow-up period involving this selected series, the prognosis of patients with systemic vasculitis and undifferentiated connective tissue syndrome appears more favorable than that of patients with rheumatoid vasculitis.

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