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Primary Hepatocellular Carcinoma After Chronic Non-A, Non-B Post-Transfusion Hepatitis

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▸Requests for reprints should be addressed to Joel E. Richter, M.D.; Section on Gastroenterology, Department of Medicine, Bowman Gray School of Medicine, 300 South Hawthorne Road; Winston-Salem, NC 27103.

Bowman Gray School of Medicine, Wake Forest University; Winston-Salem, North Carolina

Ann Intern Med. 1984;101(6):794-795. doi:10.7326/0003-4819-101-6-794
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Epidemiologic evidence of an association between hepatitis B virus and hepatocellular carcinoma is strong, but evidence of a similar association between non-A, non-B hepatitis virus infection and hepatocellular carcinoma is less clear. Reports from Japan (1-3) and Nigeria (4) suggest that hepatitis B serum markers are negative in 5% to 28% of patients with hepatocellular carcinoma. We describe the case of a patient with well-documented chronic non-A, non-B hepatitis acquired after a transfusion who developed hepatocellular carcinoma 9 years later.

A 63-year-old white man was hospitalized in November 1983 with weakness, anorexia, and weight loss of 3 weeks' duration. He


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