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Cutaneous Malignant Melanoma After Hodgkin's Disease

MARGARET A. TUCKER, M.D.; DAYTON MISFELDT, M.D., Ph.D.; C. NORMAN COLEMAN, M.D.; WALLACE H. CLARK Jr., M.D.; and SAUL A. ROSENBERG, M.D.
[+] Article and Author Information

Grant support: in part by research grants CA 05838 and CA 34233 from the National Institutes of Health.

▸Requests for reprints should be addressed to Margaret A. Tucker, M.D.; Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Room 3C-19, 7910 Woodmont Avenue; Bethesda, MD 20205.


Bethesda, Maryland; Palo Alto and Stanford, California; and Philadelphia, Pennsylvania


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(1):37-41. doi:10.7326/0003-4819-102-1-37
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Eight cutaneous malignant melanomas occurred in 6 of 1405 patients with Hodgkin's disease, although the expected incidence rate was 0.77 (relative risk, 8; 95% confidence interval, 3 to 17). One melanoma was a thin, level II lesion less than 0.76 mm thick; the rest were mostly bulky, deeply invasive lesions despite close clinical surveillance. The melanomas spread aggressively; 3 of 6 patients died within 1 to 3 years. Two of the six patients developed a second primary malignant melanoma 1 year after the first. Two of six patients had biopsy-proven dysplastic nevus syndrome, a known precursor to cutaneous malignant melanoma, and an additional 3 patients had clinical evidence of dysplastic nevus syndrome. Histologically, the malignant melanomas showed a sparse inflammatory infiltrate, an abnormal host response seen previously in cutaneous melanomas developing in immunosuppressed patients. Dysplastic nevi may identify patients at highest risk who require modified medical management.

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