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Serum Amyloid A Protein in Familial Mediterranean Fever

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Grant support: by Glassberg Amyloid Research Grant, South African Medical Research Council, and Israeli National Council for Research and Development.

▸Requests for reprints should be addressed to Mordechai Pras, M.D.; Heller Institute of Medical Research, Chaim Sheba Medical Center; 52621 Tel-Hashomer, Israel.

Heller Institute of Medical Research, Tel-Aviv University, Tel-Hashomer, Israel

Ann Intern Med. 1985;102(1):71-72. doi:10.7326/0003-4819-102-1-71
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This excerpt has been provided in the absence of an abstract.

Amyloid a protein is the subunit of amyloid fibrils that occurs in the forms of amyloidosis commonest in humans and ubiquitous in animals (1, 2). Its unique nature prompted a search for its substrate in normal serum and led to the discovery, by immunologic techniques, of serum amyloid A protein (3, 4), a high-density apolipoprotein that behaves like an acute-phase reactant and has an aminoterminal identical with that of amyloid A protein.

The first complete amino acid sequence of amyloid A protein came from a sample of amyloid from a patient with familial Mediterranean fever. A rise in serum levels


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