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Thyroid Abnormalities in Dermatitis Herpetiformis: Prevalence of Clinical Thyroid Disease and Thyroid Autoantibodies

MICHAEL J. CUNNINGHAM, M.D.; and JOHN J. ZONE, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to John J. Zone, M.D.; Division of Dermatology, University of Utah School of Medicine, 50 North Medical Drive; Salt Lake City, UT 84132.


Salt Lake City, Utah


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(2):194-196. doi:10.7326/0003-4819-102-2-194
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We studied thyroid abnormalities in 50 patients with dermatitis herpetiformis. Two patients had a history of hyperthyroidism, and 5 had hypothyroidism and were on thyroid replacement therapy. Three patients had had thyroidectomies for nodules, and 5 had asymptomatic goiter. Two patients were clinically euthyroid with elevated thyrotrophin and low normal thyroxine levels, indicating early thyroid insufficiency. Thyroid microsomal antibodies were seen in 38% of patients with dermatitis herpetiformis compared to 12% of controls. The presence of clinical or serologic thyroid abnormalities in 26 of 50 patients shows a significant but unexplained association between dermatitis herpetiformis and thyroid disease.

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