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Granulomatous Angiitis Presenting with Polymyalgia Rheumatica and Abnormal Pituitary Function

ROBIN H. MILLER, M.D.; JAMES J. S. CHEN, M.D.; ROBERT L NEY, M.D.; and PHILIP TUMULTY, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Robin H. Miller, M.D.; Division of Internal Medicine, Harvey 502, John Hopkins Hospital; Baltimore, MD 21205.


Johns Hopkins Medical Institutions; Baltimore, Maryland.


Ann Intern Med. 1985;102(2):210-211. doi:10.7326/0003-4819-102-2-210
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This excerpt has been provided in the absence of an abstract.

Various diseases of the hypothalamus have been associated with pituitary dysfunction and hypothalamic obesity syndrome. Vasculitis is a rare cause. The patient described here first presented with symptoms compatible with polymyalgia rheumatica and later developed hypothalamic obesity syndrome and a hypothalamic mass. On pathologic evaluation, the lesion was found to be granulomatous angiitis.

A 64-year-old white woman was hospitalized in December 1983 because of fatigue, weight gain, and daytime somnolence. The patient had been well until June 1982, when she developed arthralgias, fever (temperatures to 38.°C), and severe muscle tenderness with proximal muscle weakness. Laboratory studies showed an elevated sedimentation

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